David Burke (Sudeikis) is a small-time pot dealer whose clientele includes chefs and soccer moms, but no kids-after all, he has his scruples. After his stash and his cash are stolen, leaving him in major debt to his supplier, Brad (Ed Helms), he must become a big-time drug smuggler by bringing Brad's latest shipment in from Mexico. One fake wife, two pretend kids and a huge, shiny RV later, the "Millers" are headed south of the border for a Fourth of July weekend that is sure to end with a bang.